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Center on the
Early Life Origins of Disease

Publications

Below is a list of publications from the team at the Center on the Early Life Origins of Disease.
Please contact us for a list of articles published prior to 2010.

Reproductive Health and Pregnancy Outcomes

  • Ouyang F, Longnecker MP, Venners SA, Johnson S, Korrick S, Zhang J, Xu X, Christian P, Wang M, Wang X. Preconception serum DDT and B-vitamin status: independent and joint effects on women’s reproductive outcomes. AJCN. 2014 Dec;100(6):1470-8. doi: 10.3945/ajcn.114.088377. Epub 2014 Oct 22. JIF: 6.9
  • Wang G, Divall S, Radovick S, Paige D, Ning Y, Chen Z, Ji Y, Hong X, Walker S, Caruso D, Pearson C, Wang MC, Zuckerman B, Cheng TL, Wang X (corresponding author). Preterm Birth and Random Plasma Insulin Levels at Birth and in Early Childhood. JAMA 2014; 311(6):587-596 (see editorial comments). JIF: 30.026
  • Parker MG, Ouyang F, Pearson C, Gillman MW, Belfort MB, Hong X, Wang G, Heffner L, Zuckerman B, Wang X. Prepregnancy BMI and risk of preterm birth: Association heterogeneity by preterm subgroups. BMC Pregnancy and Childbirth. 2014;14(153) JIF: 2.52
  • Chen Z, Myers R, Wei T, Bind E, Kassim P, Wang G, Ji Y, Hong X, Caruso D, Bartell T, Gong Y, Strickland P, Navas-Acien A, Guallar E, Wang X. Placental Transfer and Concentrations of Cadmium, Mercury, Lead, and Selenium in Mothers, Newborns, and Young Children. J Expo Sci Environ Epidemiol. 2014 Apr 23. doi: 10.1038/jes.2014.26. [Epub ahead of print] JIF: 3.187
  • Ouyang F, Parker M, Cerda S, Pearson C, Fu L, Gilman M, Zuckerman B, Wang X. Placental Weight Mediates the Effects of Prenatal Factors on Fetal Growth: the Extent Differs by Preterm Status. Obesity. 2012 Apr 18.
  • Mestan K, Matoba N, Arguelles L, Harvey C, Ernst LM, Farrow K, Wang X. Cord blood 8-isoprostane in the preterm infant. Early Human Development. 2012, 88(8):683–689. Robison RG, Kumar R, Arguelles LM, Hong X, Wang G, Apollon S, Bonzagni A, Ortiz K, Pearson C, Pongracic JA, Bauchner H, Wang X. Maternal Smoking during Pregnancy, Prematurity and Recurrent Wheezing in Early Childhood. Pediatric Pulmonology. 2012, 47(7):666-673.
  • Liu X, Wang G, Hong X, Tsai H, Liu R, Zhang S, Wang H, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang X. Associations between Gene Polymorphisms in Fatty Acid Metabolism Pathway and Preterm Delivery in a U.S. Urban Black Population. Human Genetics. 2012 Mar;131(3):341-51.
  • Tsai H, Hong X, Chen J, Liu X, Pearson C, Ortiz K, Fu L, Hirsch E, Heffner L, Weeks DE, Zuckerman B, Wang X. Role of African Ancestry and Gene-Environment Interactions in Predicting Preterm Birth. Obstetrics & Gynecology. 2011, 18(5).
  • Kumar P, Venners S, Fu L, Pearson C, Ortiz K, Wang X. Association of antenatal steroid use with cord blood immune biomarkers in preterm births. Early Human Development. 2011; Aug;87(8):559-64.
  • Matoba N, Ouyang F, Mestan K, Porta, N, Pearson C, Ortiz K, Bauchner H, Zuckerman B, Wang X. Cord blood immune biomarkers in small for gestational age births. Journal of Developmental Origins of Health and Disease. Published online: 27 Jan 2011.
  • Mestan K, Ouyang F, Matoba N, Pearson C, Ortiz K, Wang X. Maternal obesity, diabetes mellitus, and cord blood biomarkers in large-for-gestational age infants. Journal of Pediatric Biochemistry. Volume 1, Number 3/2010/2011:217-224.
  • Kumar R, Story RE, Pongracic JA, Hong X, Arguelles L, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Bauchner H, Wang X. Maternal pre-pregnancy obesity and recurrent wheezing in early childhood. Pediatric Allergy, Immunology, and Pulmonology. 2010 Sept 23(3):183-190.
  • Mestan K, Yu Y, Matoba N, Cerda S, Demmin B, Pearson C, Ortiz K, Wang X. Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study. Pediatrics. 2010 Apr; 125(4):e891-8.

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Epigenetics and Early Life Origins of Disease

  • Wang G, Walker S, Hong X, Bartell T, Wang X. “Epigenetics and Early Life Origins of Chronic Diseases”. Journal of Adolescent Health, 2013; 52 (2S2):S14-21.
  • Wang D, Liu X, Zhou Y, Xie H, Hong X, Tsai HJ, Wang G, Liu R, Wang X. Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life. Epigenetics. 2012 Jun 1;7(6)
  • Hong X, Xin Liu, Wang X. “Genetics, Epigenetics, and GxE interactions in Food Allergy". Seminars in Immunopathology. 2012.
  • Christoffel KK, Wang X, Binns H. “Conference Report: Early Origins of Child Obesity: Bridging Disciplines and Phases of Development”. September 30-October 1, 2010. International Journal of Environmental Research and Public Health. 2012, 9(4), 1227-1262.

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Obesity and Metabolic Syndrome

  • Qin X, Li Y, Yuan H, Xie D, Tang G, Wang B, Wang X, Xu X, Xu X, Hou FF. Relationship of MTHFR gene 677C to T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes. Medicine 2015 (in press)
  • Liu R, Christoffel KK, Brickman WJ, Liu X, Gadgil M, Wang G, Zimmerman D, Chen Q, Wang B, Li Z, Xing H, Xu X, Wang X. Do static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes? Diabetes Res Clin Pract. 2014 Apr 30. pii: S0168-8227(14)00197-1. doi: 10.1016/j.diabres.2014.04.014. [Epub ahead of print] JIF: 3.187
  • Wang G, Divall S, Radovick S, Paige D, Ning Y, Chen Z, Ji Y, Hong X, Walker S, Caruso D, Pearson C, Wang MC, Zuckerman B, Cheng TL, Wang X (corresponding author). Preterm Birth and Random Plasma Insulin Levels at Birth and in Early Childhood. JAMA 2014; 311(6):587-596 (see editorial comments). JIF: 30.026
  • Wang G, Chen Z, Bartell T, Wang X. Early Life Origins of Metabolic Syndrome: The Role of Environmental Toxicants. Current Environmental Health Reports. March 2014, Volume 1, Issue 1, pp 78-89
  • Christoffel KK, Wang X, Binns H. “Conference Report: Early Origins of Child Obesity: Bridging Disciplines and Phases of Development”. September 30-October 1, 2010. International Journal of Environmental Research and Public Health. 2012, 9(4), 1227-1262.
  • Liu R, Lui X, Arguelles L, Patwari P, Zee P, Chervin R, Ouyang F, Christoffel K, Wang B, Wang G, Xu X, Wang X. A Population-based twin study on sleep duration and body composition. Obesity (Silver Spring). 2012 Jan;20(1):192-9.
  • Liu R, Brickman W, Christoffel KK, Liu X, Wang G, Arguelles L, Zhang S, Zimmerman D, Wang B, Xu X, Li Z, Xing H, Wang X. Association of Adiposity Trajectories with Insulin Sensitivity and Glycemic deterioration: A Longitudinal Study of Rural Chinese Twin Adults. Diabetes Care. July 2012, 35(7):1506-1512.
  • Wang G, Arguelles L, Liu R, Zhang S, Brickman WJ, Hong X, Tsai HJ, Wang B, Xing H, Li Z, Xu X, Wang X. Tracking Blood Glucose and Predicting Prediabetes in Chinese Children and Adolescents: A Prospective Twin Study. PLoS One. 2011, Dec; 6(12):e28573.
  • Liu R, Zee P, Chervin R, Arguelles L, Birne J, Zhang S, Christoffel K, Brickman W, Zimmerman D, Wang B, Wang G, Xu X, Wang X. Short sleep duration is associated with insulin resistance independent of adiposity in Chinese adult twins. Sleep Medicine. 2011 Oct;12(9):914-9. [This paper won The Elio Lugaresi WASM Award for Sleep Medicine conferred by the World Association of Sleep Medicine and Elsevier Sleep Medicine Sept 2011]
  • Wang G, Christoffel K, Brickman W, Hong X, Arguelles, Zhang S, Wang B, Li Z, Xing H, Tang G, Zimmerman D, Xu X, Wang X. C-Reactive Protein in Adolescent Twins: Patterns and Relationship to Adiposity. Journal of Clinical Endocrinology & Metabolism. October 2011, 96(10).
  • Wang H, Necheles J, Wang B, Birne J, Li Z, Liu X, Tang G, Xu X, Zhang S, Christoffel K, Brickman W, Zimmerman D, Wang X. Association of Adipokines with Blood Pressure in Rural Chinese Adolescents. Journal of Human Hypertension. 2011 Jun 30.
  • Wang H, Zee P, Reid K, Chervin R, Patwari P, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Wang X. Gender-specific association of sleep duration with blood pressure in rural Chinese adults. Sleep Medicine. 2011 August; 12(7):693-99.
  • Hong X, Hsu Y, Wang X. Reply to “Fat mass is a positive predictor of bone mass in adolescents.” Journal of Bone and Mineral Research. 2011 Mar;26(3):674-5. Wang G, Wang B, Ouyang F, Liu X, Tang G, Xing H, Li Z, Xu X, Wang X. The patterns of glucose tolerance and insulin resistance among rural Chinese twin children, adolescents, and young adults. Metabolism - Clinical and Experimental. 2010. 59(12):1752-1759.
  • Wang G, Liu X, Christoffel KK, Zhang S, Wang B, Liu R, Li Z, Liu X, Brickman WJ, Zimmerman D, Xu X, Wang X. Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese Adults. European Journal of Endocrinology. 2010 Aug;163(2):243-9.
  • Zhang S, Liu X, Necheles J, Tsai HJ, Wang G, Wang B, Xing H, Li Z, Liu X, Zang T, Xu X, Wang X. Genetic and environmental influences on serum lipid tracking: A population-based, longitudinal Chinese Twin Study. Pediatric Research. 2010 Oct; 68(4):316-22.
  • Ouyang F, Christoffel KK , Brickman WJ , Zimmerman D, Wang B, Xing H, Zhang S, Arguelles, Wang G, Liu R, Xu X, Wang X. Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: A population based twin study. American Journal of Clinical Nutrition. 2010; Mar;91(3):662-71.
  • Hong X, Arguelles LM, Tsai H, Zhang S, Wang G, Wang B, Liu X, Li Z, Tang G, Xing H, Xu H, Wang X. Plasma adipokines, bone mass, and hip geometry in rural Chinese adolescents. Journal of Clinical Endocrinology and Metabolism. 2010;95(4):1644-1652.
  • Hong X, Arguelles LM, Liu X, Tsai H, Hsu Y, Wang B, Zhang S, Li Z, Tang G, Liu X, Yang J, Xu X, Langman C, Wang X. Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese Adolescents. Journal of Bone and Mineral Research. 2010; 25(7):1544-1554.
  • Yu Y, Wang B, Brickman W, Zimmerman D, Li Z; Wang L; Liu X; Tang G; Xing H; Xu X, Wang X: Association of central adiposity with prediabetes and decreased insulin sensitivity in rural Chinese normal-weight and overweight women. Metabolism. 2010; 59:1047–1053.

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Growth and Development

  • Hong X, Tsai HJ, Liu X, Li Z, Liu X, Tang G, Xing H, Yang J, Wang B, Feng Y, Xu X, Xu X, Wang X. . 2008 Nov;93(11):4511-8.
  • Ouyang F, Lu B, Wang B, Yang J, Li Z, Wang L, Tang G, Xing H, Xu X, Chervin R, Zee P, Wang X. Sleep Patterns among Rural Chinese Twin Adolescents. Sleep Medicine. 2008;(10):479-489.

Pulmonary Function, Respiratory Health, Food Allergy and Related Conditions

  • Hong X, Han K, Ladd-Acosta C, Hansen KD, Tsai H, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide association study of food allergy identifies peanut allergy-specific loci and evidence of epigenetic mediation in U.S. children. Nature Communications 2015 DOI:10.1038/ncomms7304
  • Warren CM, Gupta RS, Sohn MW, Oh EH, Lal N, Garfield GF, Caruso D, Wang X, Pongracic, JA. Differences in empowerment and quality of life among parents of children with food allergy. Ann Allergy Asthma Immunol 2015; 1-9.
  • Tripathi P, Hong X, Caruso D, Gao P*, Wang X* (co-corresponding authors). Genetic Determinants in the Development of Sensitization to Environmental Allergens in Early Childhood. Immunity, Inflammation and Disease 2014; 2(3):193-204
  • Bousquet J, Gern JE, Martinez FD, Anto JM, Johnson CC, Holt PG, Lemanske RF Jr, Le Souef PN, Tepper R, von Mutius ERM, Arshad SH, Bacharier LB, Becker A, Belanger K, Bergstrom A, Bernstein D, Cabana MD, Carroll KN, Castro M, Cooper PJ, Gillman MW, Gold DR, Henderson J, Heinrich J, Hong S-J, Jackson DJ, Keil T, Kozyrskyj AL, Lodrup-Carlsen K, Miller RL, Momas I, Morgan WJ, Noel P, Ownby DR, Pinart M, Ryan P, Schwaninger JM, Sears MR, Simpson A, Smit HA, Stern D, Subbarao P, Valenta R, Wang X, Weiss ST, Wood R, Wright AL, Wright RJ, Togias A, Gergen PJ. Birth cohorts in asthma and allergic diseases: Report of a NIAID, NHLBI MeDALL joint workshop. Journal of Allergy & Clinical Immunology. Volume 133, Issue 6, June 2014, Pages 1535–1546. JIF: 12.047
  • Liu X, Arguelles L, Zhou Y, Wang G, Chen Q, Tsai H, Hong X, Liu R, Price H, Pearson C, Apollon S, Cruz N, Schleimer R, Langman C, Pongracic J, Wang X. Pediatric Research. (in press) Hong X, Xin Liu, Wang X. “Genetics, Epigenetics, and GxE interactions in Food Allergy". Seminars in Immunopathology. 2012.
  • Hong X, Caruso D, Kumar J, Liu R, Liu X, Wang G, Wang X. . Allergy. 2012. Dec;67(12):1538-46.
  • Zhang S, Liu X, Kim JS, Ouyang F, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Wang X. Association between short sleep duration and the risk of sensitization to food and aero allergens in Rural Chinese Adolescents. Clinical and Experimental Allergy. 2011 Apr;41(4):547-55.
  • Liu X, Wang GY, Hong XM, Wang D, Tsai HJ, Zhang SC, Arguelles L, Kumar R, Wang HJ, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt R, Pongracic J, Price HE, Langman C, Wang X. Gene-Vitamin D Interactions on Food Sensitization: A prospective birth cohort study. Allergy. 2011 Nov;66(11):1442-8.
  • Hong X, Wang G, Liu X, Kumar R, Tsai H, Arguelles L, Hao K, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Caruso D, Pongracic J, Schleimer R, Holt P, Bauchner H, Wang X. Gene Polymorphisms, Breastfeeding and Development of Food Sensitization in Early Childhood. Journal of Allergy & Clinical Immunology. 2011 Aug;128(2):374-381.e2.
  • Kumar R, Tsai H, Hong X, Pearson C, Fu M, Pongracic J, Bauchner H, Wang X. African Ancestry, Early Life Exposures, and Respiratory Morbidity in Early Childhood. Clinical and Experimental Allergy. 2011 Sep 25.
  • Kumar R, Tsai HJ, Hong X, Liu X, Wang G, Pearson C, Ortiz K, Fu L, Pongracic J, Bauchner H, Wang X: Race, Ancestry and Development of Food Allergen Sensitization in Early Childhood. Pediatrics. 2011 Oct;128(4):e821-9.
  • Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang X. Does genetic regulation of IgE begin in-utero? Evidence from TH1/TH2 gene polymorphisms and cord blood total IgE. Journal of Allergy & Clinical Immunology. 2010;126(5):1059-1067.
  • Springston EE, Shulruff J, Smith B, Wang X, Pongracic J, Holl J, Gupta RS. Variations in quality of life among caregivers of food-allergic children. Annals of Allergy, Asthma & Immunology2010 Oct;105(4):287-294.
  • Gupta RS, Springston EE, Kim JS, Smith B, Pongracic JA, Wang X, Holl J. Food allergy knowledge, attitudes, and beliefs of the primary care physicians. Pediatrics. 2010;125:126-32.
  • Kumar R, Caruso DM, Arguelles L, Kim J, Schroeder A, Rowland B, Meyer KE, Schwartz K, Birne J, Ouyang F, Pongracic JA, Wang X. Early life eczema, food introduction and risk of food allergy in children. Pediatric Allergy, Immunology, and Pulmonology. 2010 Sept;23(3):175-82.
  • Gupta RS, Springston EE, Smith B, Kim JS, Pongracic JA, Wang X, Holl J. Food allergy knowledge, attitudes, and beliefs of parents with food-allergic children in the United States. Pediatric Allergy and Immunology. 2010;21:927-34.

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Osteoporosis

  • Arguelles LM, Ouyang F, Wang X. “Bone Growth Patterns in Rural Chinese Children and Adolescents”. In: Handbook of Growth and Growth Monitoring in Health and Disease. Victor R. Preedy (eds). Springer, 2011.
  • Ouyang F, Wang B, Arguelles LM, Xu X, Yang J, Li Z, Wang L, Liu X, Tang G, Xing H, Langman C, Wang X. Bone growth patterns in Chinese children and adolescents: a 6-year follow-up study provides evidence for sexual dimorphism and tracking. Archives of Osteoporosis. Vol. 2(1-2):29-43. Published online: 30 November 2007.

Prevention of Stroke and Cardiovascular Disease

  • Wang Q, Xie, D, Xu X, Qin X, Tang G, Wang B, Wang Y, Hou F, Xu X, Wang X. Blood pressure and renal function decline: a 7-year prospective cohort study in middle-aged rural Chinese men and women. J Hypertens. 2015 Jan;33(1):136-43. doi: 10.1097/HJH.0000000000000360.
  • Zheng M, Xu X, Wang X, Huo Y, Xu X, Qin X, Tang G, Xing H, Fan F, Cui W, Yang X. Age, arterial stiffness, and components of blood pressure in Chinese adults. Medicine 2014 Dec;93(29):e262. doi: 0.1097/MD.0000000000000262.
  • Zheng M, Huo Y, Wang X, Xu X, Qin X, Tang G, Xing H, Fan F, Li J, Zhang Y, Wang B, Xu X, Yang X, Chen Y, Qian G. A prospective study on pulse wave velocity (PWV) and response to anti-hypertensive treatments: PWV determines BP control. Int J Cardiol. 2014 Oct 22;178C:226-231. doi: 10.1016/j.ijcard.2014.10.049. [Epub ahead of print]
  • Qin X, Fan F, Chen F, Chen Y, Cheng X, Cui Y, Zhang Y, Li J, Xu X, Xu X, Huo Y, Wang X. Folic Acid Supplementation with and without vitamin B6 and Revascularization Risk: A Meta-Analysis of Randomized Controlled Trials Clin Nutr. 2014 Aug;33(4):603-12. JIF: 4.581
  • Qin X, Huo Y, Xie D, Hou F, Xu X, Wang X. Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: a meta-analysis of randomized controlled trials. Clinical Nutrition. 2012 Dec 28. pii: S0261-5614(12)00280-4.
  • Qin X, Cui Y, Shen L, Sun N, Zhang Y, Li J, Xu X, Wang B, Xu X, Huo Y, Wang, X. Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled tirals. International Journal of Cancer. 2013 Jan 22.
  • He M, Qin X, Cai Y, Sun L, Xu X, Wang B, Tang G, Xing H, Wang X, Xu X, Xu X, Huo Y. Unrecognized lower extremity peripheral arterial disease prevalence and the associated factors in Chinese hypertensive adults. American Journal of Cardiology. 2012 Dec 1; 110(11):1692-8.
  • Qin X, Cai Y, He M, Sun L, Fu J, Zhang Y, Li J, Wang B, Xing H, Tang G, Wang X, Xu X, Xu X, Huo Y. Prevalence of obesity, abdominal obesity and the associated factors in hypertensive adults aged 45 to 75 years. Clinical Nutrition. 2012 Aug 21; pii: s0261-5614(12)00172-0.
  • Qin X, Li J, Zhang Y, Ma W, Fan F, Wang B, Xing H, Tang G, Wang X, Xu X, Xu X, Huo Y. Prevalence and associated factors of diabetes and impaired fasting glucose in Chinese hypertensive adults aged 45 to 75 years. PLoS One. 2012;7(8):e42538.
  • Huo Y, Qin X, Wang J, Sun N, Zeng Q, Xu X, Liu L, Xu X, Wang X. Efficacy of Folic Acid Supplementation in Stroke Prevention: New Insight from a Meta-analysis. International Journal of Clinical Practice. 66 (6), 544-551.
  • Qin X, Li J, Cui Y, Liu Z, Zhao Z, Ge J, Guan D, Hu J, Wang Y, Zhang F, Xu X, Wang X, Xu X, Huo Y. MTHFR C677T and MTR A2756G Polymorphisms and the Homocysteine Lowering Efficacy of Different Doses of Folic Acid in Hypertensives Chinese Adults. Nutrition Journal. 2012 Jan 10;11:2.
  • Qin X, Li J, Cui Y, Liu Z, Zhao Z, Ge J, Guan D, Hu J, Wang Y, Zhang F, Xu X, Wang X, Xu X, Huo Y. Effect of folic acid intervention on ALT concentration in hypertensives without known hepatic disease: a randomized, double-blind, controlled trial. European Journal of Clinical Nutrition. 2012; 66:541-548.

Statistical Methods

  • Hao K, Wang X. Incorporating individual error rate into association test of unmatched case-control design. Human Heredity. 2004;58:154-63
  • Hao K, Xu X, Laird N, Wang X, Xu X. Power estimation of multiple SNP association test of case-control study and application. Genetic Epidemiology. 2004; 26:22-30

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